Mitochondrial DNA (mtDNA) mutations escalate with increasing age in higher organisms. However, it has so far been difficult to experimentally determine whether mtDNA mutation merely correlates with age or directly limits lifespan. A recent study shows that budding yeast can also lose functional mtDNA late in life. Interestingly, independent studies of replicative lifespan (RLS) and of mtDNA‐deficient cells show that the same mutations can increase both RLS and the division rate of yeast lacking the mitochondrial genome. These exciting, parallel findings (...) imply a potential causal relationship between mtDNA mutation and replicative senescence. Furthermore, these results suggest more efficient methods for discovering genes that determine lifespan. (shrink)

Group musical performance, especially large instrumental ensembles, present the outward appearance of an asymmetric, temporally immediate stimulus-response relationship between conductor and ensemble. Interestingly, anecdotal reports from both conductors and performers indicate a degree of variability in the timing of orchestral response to the conductor’s gestures. This observation is not present in anecdotal accounts of other instrumental ensemble settings, like wind bands, but commonplace occurrence among orchestral musicians indicates the potential presence of greater complexity in the observed relationship. This study investigates (...) both the quality and quantity of temporal lag between conductor and ensemble in two common instrumental ensemble configurations – wind bands and orchestras – in an effort to describe the interplay present within conducted group performance. The findings indicate that the anecdotally identified lag is present within all ensemble types, and that it presents a flexible, dynamic temporal relationship between conductor and ensemble. Additionally, both the quantity and quality of lag values are significantly different between ensemble types, experience levels, and musical content. Several avenues for future research are identified, and confounds within the sampled ensembles are examined for their potential roles in the observed relationships. (shrink)

Catholic health care is often viewed as antithetical to secular conceptions of autonomy. This view can engender calls to protect “choice” in Catholic facilities. However, this view is built on a fundamental misunderstanding of the Ethical and Religious Directives for Catholic Health Care Services (ERDs). This commentary, which responds to “Principled Conscientious Provision: Referral Symmetry and Its Implications for Protecting Secular Conscience,” by Abram Brummett et al., seeks to demonstrate the nuance of the ERDs as well as to address some (...) of the challenges various Catholic identities have when interpreting and living out the ERDs so that all patients receive high-quality, compassionate care. By highlighting the Church's desire to protect all people at every stage, I hope to dispel the caricatures that often result from misunderstandings by Catholics and non-Catholics alike. (shrink)

This essay asks: How do the realities of embodied trauma inflicted by racism interface with virtue theory? This question illuminates two lacunae in virtue theory. The first is attention to race. We argue that the contemporary academic virtue literature performs largely as a White space, failing to address virtue theory’s role in the social construction of race, ignoring the rich and vibrant resources on virtue ethics alive within the Black theological tradition that long antedates Alasdair MacIntyre’s After Virtue, and segregating (...) the emerging literature on race and virtue from the broader discourse. The second is lack of attention to embodiment. More precisely, contemporary virtue theory, informed largely by Aristotle, Aquinas, and MacIntyre, has no conceptual space to theorize the body’s role acquiring and deploying virtue and vice. To explore this nexus, we draw on racial trauma therapist Resmaa Menakem, Katie Walker Grimes, and Howard Thurman’s Jesus and the Disinherited to challenge contemporary virtue theory and open new possibilities for a robustly corporate, enfleshed theological virtue ethic. (shrink)

The effects of research ethics training on medical students' attitudes about clinical research are examined. A preliminary randomized controlled trial evaluated 2 didactic approaches to ethics training compared to a no-intervention control. The participant-oriented intervention emphasized subjective experiences of research participants (empathy focused). The criteria-oriented intervention emphasized specific ethical criteria for analyzing protocols (analytic focused). Compared to controls, those in the participant-oriented intervention group exhibited greater attunement to research participants' attitudes related to altruism, trust, quality of relationships with researchers, desire (...) for information, hopes about participation and possible therapeutic misconception, importance of consent forms, and deciding quickly about participation. The participant-oriented group also agreed more strongly that seriously ill people are capable of making their own research participation decisions. The criteria-oriented intervention did not affect learners' attitudes about clinical research, ethical duties of investigators, or research participants' decision making. An empathy-focused approach affected medical students' attunement to research volunteer perspectives, preferences, and attributes, but an analytically oriented approach had no influence. These findings underscore the need to further examine the differential effects of empathy-versus analytic-focused approaches to the teaching of ethics. (shrink)

The effects of research ethics training on medical students' attitudes about clinical research are examined. A preliminary randomized controlled trial evaluated 2 didactic approaches to ethics training compared to a no-intervention control. The participant-oriented intervention emphasized subjective experiences of research participants. The criteria-oriented intervention emphasized specific ethical criteria for analyzing protocols. Compared to controls, those in the participant-oriented intervention group exhibited greater attunement to research participants' attitudes related to altruism, trust, quality of relationships with researchers, desire for information, hopes about (...) participation and possible therapeutic misconception, importance of consent forms, and deciding quickly about participation. The participant-oriented group also agreed more strongly that seriously ill people are capable of making their own research participation decisions. The criteria-oriented intervention did not affect learners' attitudes about clinical research, ethical duties of investigators, or research participants' decision making. An empathy-focused approach affected medical students' attunement to research volunteer perspectives, preferences, and attributes, but an analytically oriented approach had no influence. These findings underscore the need to further examine the differential effects of empathy-versus analytic-focused approaches to the teaching of ethics. (shrink)

This essay explicates a structural theory of the historical evolution of world-systems. Rather than using societies as the unit of analysis the authors use intersocietal interaction networks (world-systems). This enables them to take theoretical account of the systemic development processes that are regional and inter-regional in scope and to formulate a more powerful theory that explains how thousands of egalitarian small-scale world-systems evolved, expanded and merged to become the hierarchical and global world-system of today.

Powerful conversations between His Holiness the Dalai Lama and leading scientists on the most pressing issue of our time. Engage with leading scientists, academics, ethicists, and activists, as well as His Holiness the Dalai Lama and His Holiness the Karmapa, who gathered in Dharamsala, India, for the twenty-third Mind and Life conference to discuss arguably the most urgent questions facing humanity today: What is happening to our planet? What can we do about it? How do we balance the concerns of (...) people against the rights of animals and against the needs of an ecosystem? What is the most skillful way to enact change? And how do we fight on, even when our efforts seem to bear no fruit? Inspiring, edifying, and transformative, this should be required reading for any citizen of the world. (shrink)

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly ‘queer’ approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity (...) and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms. (shrink)

Debate on free will with Christian List, Gregg Caruso, and Cory Clark. The exchange is focused on Christian List's book Why Free Will Is Real.

BackgroundChildhood adversity is linked to adverse health in adulthood. One posited mechanistic pathway is through physiological responses to acute stress. Childhood adversity has been previously related to both exaggerated and blunted physiological responses to acute stress, however, less is known about the psychological mechanisms which may contribute to patterns of physiological reactivity linked to childhood adversity.ObjectiveIn the current work, we investigated the role of challenge and threat stress appraisals in explaining relationships between childhood adversity and cortisol reactivity in response to (...) an acute stressor.MethodsUndergraduate students completed an online survey that included general demographic information and the Risky Families Questionnaire 24 h before a scheduled lab visit. In the lab, a research assistant collected a baseline salivary cortisol sample. Following the baseline period, participants were read instructions for the Trier Social Stress Test, a validated psychological lab stressor. Next, they completed a challenge vs. threat task appraisal questionnaire and completed the speech and math portion of the TSST. Twenty minutes following the start of the TSST, a second salivary sample was collected to measure changes in salivary cortisol following the TSST.ResultsLinear regression analyses adjusted for age, sex, childhood socioeconomic status, and baseline cortisol levels, showed childhood adversity associated with changes in cortisol levels [B = –0.29 t = –2.35, p = 0.02, R2=0.07]. Linear regression analyses controlling for age, sex, and childhood SES showed childhood adversity associated with both challenge [B = –0.52 t = –5.04, p < 0.001, R2=0.24] and threat [B = 0.55 t = 5.40, p < 0.001, R2=0.27] appraisals. Significant indirect effects of childhood trauma on cortisol reactivity were observed through challenge appraisals [B = –0.01 ], and threat appraisals [B = –0.01 ].ConclusionChildhood adversity may contribute to blunted cortisol reactivity, a pattern of response which is linked to obesity, addiction, and other behavior-related diseases. Our findings suggest that this relationship is in part a product of stress appraisals. (shrink)

Dunn, Geoffrey D As a seminary student I was taught that a homily ought to end with a eucharistic link. Mature reflection leads me to conclude that the entire homily is itself the eucharistic link. It joins together the interplay of the life of the assembly and the Scriptures, on the one hand, and the great prayer of thanksgiving on the other. My reflections are missing the element of the life of the assembly, which can be supplied only by (...) individual preachers in touch with their communities, but hopefully they provide something of the reason why, on this particular occasion, the assembly can move on to offer God thanks. (shrink)

In this book James D. G. Dunn explores the nature of the religious experiences that were at the forefront of emerging Christianity.

Dunn, Geoffrey D In the past two weeks we have heard of covenants God made with people: the covenant with Noah symbolised by the rainbow and the covenant with Abraham symbolised by the stars in the night sky. God made fantastic promises and it would seem that God asked for little in return. Perhaps that is unfair. Noah had to suffer seeing the rest of humanity destroyed and Abraham endured the torment of preparing his son for sacrifice. They both (...) offered a significant display of faith and their descendants enjoyed the benefits. (shrink)

Dunn, Geoffrey D Older Catholics would have grown up hearing about the sacrifice of the Mass, while in the last fifty years we have increasingly spoken of the celebration of the eucharist. Of course, the eucharist is sacrifice, but it is other things besides, like meal and celebration, and the word 'sacrifice' is easy to misinterpret. For many of us the word 'sacrifice' conjures up thoughts of the killing and slaughter of animals or even people. It is true that (...) the word can mean this, but it has a much broader meaning. To sacrifice something is to remove it from the realm of the everyday and hand it over or dedicate it to some other purpose. Thus, a bloodless sacrifice, like the libation or pouring out of wine, is the offering up of something for someone else's use rather than one's own. Naturally, the killing of a living victim ensures that one cannot change one's mind later on and take it back, especially when the burnt sacrificial animal has often then been eaten by those who had participated in or witnessed the ritual slaughter. (shrink)

El artículo estudia los comentarios de Agustín sobre María en sus dieciocho homilías de Navidad, señalando la frecuencia y los contextos en que estas ideas aparecen, y el propósito que tienen. Como prueba del naciente culto a María en la cristiandad del Norte de África, el autor señala el interés de Agustín por María en sí misma, o por lo que ella significaba para la cristología.

Building on the advances made by feminist reconsiderations of methods, methodology and epistemology, this paper calls for an alliance between feminist social science and the emerging field of queer theory. By challenging traditional scientific approaches to research on sexual minority groups, a distinctly ‘queer’ approach is advocated that adopts a reflexive position on subjectivity and sexuality. While essentialist approaches privilege gay/lesbian, man/woman, and object/subject, this approach advances a framework of critical sexualities that moves social science into an arena of inclusivity (...) and multiple identities, rather than reductionistic categorical thought. The implications are clear: a rethinking of identity categories that transcend stagnant dualisms. (shrink)

Parece que san Agustín, en sus "sermones ad populum" proporciona muy poca información concreta sobre las realidades sociales de riqueza y pobreza. El artículo examina esta información para comentar la importancia que tenía para Agustín el aspecto social de la pobreza.

Augustine’s Epistulae 23A*, 23*, and 22*, written in late 419 and early 420, present his involvement in the dispute concerning the translation of Honorius to Caesarea Mauretaniae (modern Cherchell), a city Augustine had visited in September 418 while fulfilling a commission from Zosimus of Rome. The translation of bishops from one church to another had been condemned by the 325 Council of Nicaea. The three letters are difficult to interpret because the information to his three correspondents (Possidius of Calama, Renatus, (...) a monk of Caesarea Mauretaniae, and Alypius of Thagaste, who was in Italy at the time) seems to differ. A careful reading reveals that not only did Augustine’s knowledge of the situation change over time, but that the stress he placed on differing elements of that situation also changed depending upon the correspondent. The letters also disclose the involvement of Boniface I of Rome, Zosimus’ successor, and the complex relationship of the African churches with the bishop of Rome, especially in the matter of judicial appeal. What is suggested here is that Augustine, without saying so, seemed to be aware of the criteria Boniface had employed in another translation controversy, which was the approved translation of Perigenes as bishop of Corinth, and that, if applied to Honorius, this would lead the Roman bishop to reach a very different conclusion. (shrink)